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GBARunner2 is an open-source hypervisor that runs GBA games on DS / DSi / 3DS in DS mode. Basically, like Nintendont does for running GameCube games on Wii.
Along with what this wiki has to offer, the GBARunner compatibility lists have a lot of useful information:
ヘルプが必要ですか？Discordサーバーに参加してください：DS⁽ⁱ⁾ Mode Hacking!（英語のみ）